Description

5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl-2'-Deoxyadenosine-3'-O-Succinic Acid is a high-purity, protected nucleoside phosphoramidite precursor, a critical building block in automated oligonucleotide synthesis. Its value lies in enabling the precise and efficient incorporation of deoxyadenosine into synthetic DNA strands for research and therapeutic applications. This compound is essential for biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, aptamers, primers, and probes. The CAS number for this material is 130150-81-1.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense drugs, siRNA, and aptamers for clinical development.
• Research Reagent Synthesis: Creation of custom primers, probes, and gene fragments for molecular biology and diagnostics.
• Next-Generation Sequencing (NGS): Synthesis of oligonucleotide libraries and capture probes.
• CRISPR-Cas9 System Components: Manufacturing of guide RNAs (gRNAs) and related nucleic acid constructs.
• Diagnostic Kit Production: For the development of PCR assays, microarrays, and other molecular diagnostic tools.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl-2'-Deoxyadenosine-3'-O-Succinic Acid
CAS No.	130150-81-1
Molecular Formula	C43H41N5O11
Molecular Weight	803.82 g/mol
Synonyms	DMTr-dA(Pac)-Succinate; N6-Pac-5'-DMTr-dA-3'-Succinate; 2'-Deoxyadenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[2-(phenoxyacetyl)]-, 3'-(hydrogen succinate); dA(Pac) Phosphoramidite Synthon; Protected Deoxyadenosine-3'-Succinate; 5'-DMTr-N6-Pac-dA-3'-succinic acid; DMT-N6-PAC-dA-CE Phosphoramidite precursor
EINECS	Contact for details

Quality Control

Every batch of our 5'-O-(4,4'-Dimethoxytrityl)-N6-Phenoxyacetyl-2'-Deoxyadenosine-3'-O-Succinic Acid is manufactured and tested under strict quality systems suitable for pharmaceutical intermediates. We provide comprehensive analytical data to ensure consistency, purity, and suitability for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) detailing purity by HPLC, identity confirmation, and moisture content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.