Description

Cytidine-2-14C 5'-Monophosphate Ammonium Salt is a radiolabeled nucleotide derivative where the carbon-14 isotope is specifically incorporated at the 2-position of the cytidine base. This compound is essential for tracing and quantifying nucleotide metabolism, DNA/RNA synthesis, and related enzymatic pathways in biochemical and pharmacological research. It is a critical tool for scientists in pharmaceutical development, metabolic studies, and molecular biology who require precise tracking of nucleotide incorporation and turnover.

Application

• Tracer Studies in Nucleotide Metabolism: Used to investigate the biosynthesis, catabolism, and salvage pathways of nucleotides within cells and tissues.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed as a radiolabeled probe to study the absorption, distribution, metabolism, and excretion (ADME) of nucleotide-based pharmaceuticals.
• Enzyme Assay Substrate: Serves as a specific substrate for enzymes such as kinases, phosphatases, and nucleotidyltransferases to measure activity and inhibition.
• Nucleic Acid Research: Utilized in the study of RNA synthesis, processing, and degradation mechanisms.
• Biochemical Pathway Analysis: Applied in metabolic flux analysis to map and quantify fluxes through central metabolic pathways involving nucleotides.
• Quality Control Reference Standard: Acts as an authenticated reference material in analytical laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	Cytidine-2-14C 5'-Monophosphate Ammonium Salt
CAS No.	130150-79-7
Molecular Formula	C9H16N3O8P * xNH3 (x typically 1-2)
Molecular Weight	Contact for details
Synonyms	2'-Deoxycytidine-2-14C 5'-monophosphate ammonium salt; Cytidine 5'-monophosphate-2-14C ammonium salt; 14C-CMP ammonium salt; CMP-2-14C ammonium salt; Cytidylic-2-14C acid ammonium salt; 5'-CMP-2-14C ammonium salt; [2-14C]Cytidine 5'-monophosphate ammonium salt
EINECS	Contact for details

Quality Control

Every batch of Cytidine-2-14C 5'-Monophosphate Ammonium Salt is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including radiochemical purity and chemical purity analysis by HPLC, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing specific activity, purity, and analytical methods are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach ambient temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied in solution)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.