Description

4'-Azidothymidine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and a versatile intermediate for synthesizing novel antiviral agents and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside-based therapeutics, particularly for antiviral applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drug candidates.
• Biochemical Research: Used as a probe or substrate in enzymatic studies to investigate mechanisms of viral replication and cellular metabolism.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new analogs with improved efficacy and reduced toxicity.
• Antiviral Agent Development: Serves as a core scaffold for creating potential therapeutics targeting HIV, hepatitis, and other viral diseases.
• Labeling and Conjugation: The azido functional group allows for bioorthogonal click chemistry applications, useful in bioconjugation and labeling studies.

Basic Information

Product Name	4'-Azidothymidine
CAS No.	130108-72-4
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	AZT Azido Derivative; 3'-Azido-3'-deoxythymidine Azido Analog; 1-[(2R,4S,5R)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Azidothymidine; 4'-AZT; NSC 406140; Azido-d4T (related analog name)
EINECS	Contact for details

Quality Control

Our 4'-Azidothymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current industry standards, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.