Description

Bicyclo[2.2.1]Heptane-2-Carbonyl Chloride, 4,7,7-Trimethyl-3-Oxo-, (1R-Exo)- (9Ci) is a high-purity, chiral bicyclic acid chloride derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. Its unique sterically hindered structure and reactive carbonyl chloride group make it invaluable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemicals, and specialty fine chemicals who require reliable, high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, stereochemically defined molecules.
• Asymmetric Synthesis: Used as a chiral auxiliary or electrophile in stereoselective reactions, including Friedel-Crafts acylation, amide coupling, and esterification to introduce the bicyclo[2.2.1]heptane scaffold.
• Agrochemical Research: Intermediate in the development of novel pesticides and herbicides where the rigid, lipophilic bicyclic structure can enhance biological activity and environmental stability.
• Material Science: Potential monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties derived from its rigid, aliphatic core.
• Flavor & Fragrance Chemistry: Starting material for synthesizing complex terpenoid-like aroma compounds, leveraging its camphor-related structural motif.
• Catalyst & Ligand Development: Precursor for synthesizing novel chiral ligands or organocatalysts used in homogeneous catalysis.

Basic Information

Item	Details
Product Name	Bicyclo[2.2.1]Heptane-2-Carbonyl Chloride, 4,7,7-Trimethyl-3-Oxo-, (1R-Exo)- (9Ci)
CAS No.	129940-80-3
Molecular Formula	C11H15ClO2
Molecular Weight	214.69 g/mol
Synonyms	(1R-exo)-4,7,7-Trimethyl-3-oxobicyclo[2.2.1]heptane-2-carbonyl chloride; (1R)-4,7,7-Trimethyl-3-oxo-2-bicyclo[2.2.1]heptanecarbonyl chloride; exo-(+)-3-Oxo-4,7,7-trimethylbicyclo[2.2.1]heptane-2-carbonyl chloride; 2-Norbornanecarbonyl chloride, 4,7,7-trimethyl-3-oxo-, (1R,2R,4R)-; Chiral Camphor Acid Chloride derivative; (1R)-Camphor-10-carbonyl chloride (derivative); Bicyclo[2.2.1]heptane-2-carbonyl chloride, 3-oxo-4,7,7-trimethyl-, (1R,2R,4R)-
EINECS	Contact for details

Quality Control

Our production of Bicyclo[2.2.1]Heptane-2-Carbonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and cGMP manufacturing. All batches are analyzed using advanced techniques including HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing purity, assay, impurity profile, and physical properties is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.