Description

1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(Trifluoromethyl)- (9Ci) is a high-value, reactive chemical intermediate essential for advanced synthesis. Its core value lies in the trifluoromethylpyrazole scaffold, which is a critical pharmacophore for imparting desirable metabolic stability and lipophilicity in active molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients. The CAS number for this product is 129768-24-7.

Application

This specialized acid chloride is a key building block for the synthesis of amides and esters, enabling the rapid introduction of the 1-methyl-3-(trifluoromethyl)pyrazole moiety. Its primary applications include:

• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs), particularly in candidates targeting inflammation, oncology, and central nervous system disorders.
• Agrochemical Intermediate: Construction of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Used in the development of specialty polymers and functional materials with tailored properties.
• Contract Research & Manufacturing (CRO/CMO): Serves as a critical reagent for custom synthesis and process development services.
• Library Synthesis: Ideal for creating diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Item	Details
Product Name	1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(Trifluoromethyl)- (9Ci)
CAS No.	129768-24-7
Molecular Formula	C6H4ClF3N2O
Molecular Weight	212.56 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride; 1-Methyl-3-(trifluoromethyl)pyrazole-5-carbonyl chloride; 5-Carbonyl chloride-1-methyl-3-trifluoromethylpyrazole; 1-Methyl-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid chloride; 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid chloride; 129768-24-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrazole-5-Carbonyl Chloride, 1-Methyl-3-(Trifluoromethyl)- adheres to stringent quality protocols suitable for research and industrial scale use. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), impurity profile, and physical characteristics are provided and available upon request. Our quality management system supports traceability and meets the demands of cGMP-compliant synthesis where applicable.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids, bases, and oxidizing agents. Ensure adequate ventilation in the storage area and handle in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.