Description

Pyridine,2-[[(1,1-Dimethylethyl)dimethylsilyl]methyl]-(9Ci) is a specialized organosilicon-protected pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which shields sensitive functional groups during complex multi-step reactions, enabling the synthesis of high-value fine chemicals and pharmaceuticals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity, reliable intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly in nucleoside and heterocyclic chemistry.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the pyridine moiety and silicon protection are required for specific biological activity.
• Ligand and Catalyst Preparation: Acts as a precursor for creating sophisticated nitrogen-containing ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for organic electronics, such as OLEDs and conductive polymers.
• Process Chemistry Development: Valued in scale-up and optimization of synthetic routes in fine chemical production due to its stability and predictable reactivity.
• Academic & Industrial R&D: A vital tool for methodological development in organic synthesis, including new cross-coupling and C-H functionalization reactions.

Basic Information

Item	Details
Product Name	Pyridine,2-[[(1,1-Dimethylethyl)dimethylsilyl]methyl]-(9Ci)
CAS No.	129750-61-4
Molecular Formula	C12H21NSi
Molecular Weight	207.39 g/mol
Synonyms	2-((tert-Butyldimethylsilyl)methyl)pyridine; 2-((tert-Butyldimethylsilyl)methyl)pyridine; 2-[(tert-Butyldimethylsilyl)methyl]pyridine; 2-(tert-Butyldimethylsilylmethyl)pyridine; 2-Pyridylmethyl tert-butyldimethylsilane; (2-Pyridylmethyl)dimethyl(tert-butyl)silane; TBDMS-2-Picolyl; NSC 339063
EINECS	Contact for details

Quality Control

Our production of Pyridine,2-[[(1,1-Dimethylethyl)dimethylsilyl]methyl]-(9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by modern analytical techniques including NMR, GC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP and REACH requirements for advanced intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.