Description

O(6)-Benzyl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically designed for advanced research and synthesis applications. This compound is a critical building block and protective group intermediate in oligonucleotide synthesis and medicinal chemistry, enabling the study of DNA structure, function, and repair mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside-based therapeutics, antisense oligonucleotides, and biochemical probes.

Application

• Oligonucleotide Synthesis: Serves as a key protected intermediate in the solid-phase and solution-phase synthesis of modified DNA strands.
• Medicinal Chemistry Research: Used as a precursor in the development of novel nucleoside analogs with potential antiviral or anticancer activity.
• Biochemical Studies: Employed in research investigating DNA alkylation damage, repair pathways, and the role of specific guanine modifications.
• Protecting Group Strategy: The O(6)-benzyl group provides selective protection for guanine residues during complex multi-step synthetic sequences.
• Reference Standard: Can be used as a high-purity analytical standard for quality control in related chemical and pharmaceutical production.

Basic Information

Product Name	O(6)-Benzyl-2'-Deoxyguanosine
CAS No.	129732-90-7
Molecular Formula	C₁₇H₁₉N₅O₄
Molecular Weight	357.36 g/mol
Synonyms	2'-Deoxy-O6-benzylguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(phenylmethoxy)-1H-purin-2-one; O6-Bn-dG; 6-Benzyloxy-2'-deoxyguanosine; 2'-Deoxy-6-O-benzylguanosine; 1,9-Dihydro-9-[(2-deoxy-β-D-erythro-pentofuranosyl)oxy]-6-(benzyloxy)purin-2(3H)-one; O6-Benzyl-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our O(6)-Benzyl-2'-Deoxyguanosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.