Description

Emakalim is a potent and selective ATP-sensitive potassium (KATP) channel opener, widely recognized in pharmacological research. This compound is valued for its role as a reference standard in cardiovascular and smooth muscle studies, providing critical insights into vasodilation and cellular electrophysiology. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on ion channel biology and drug discovery for hypertension and related conditions.

Application

• Pharmacological Research: Used as a reference standard in studies investigating KATP channel function and modulation.
• Cardiovascular Research: Employed in preclinical models to study vasodilation, coronary blood flow, and potential anti-hypertensive mechanisms.
• Smooth Muscle Physiology: Applied in research on bronchial, vascular, and uterine smooth muscle relaxation.
• Drug Discovery & Development: Serves as a key tool compound for screening and validating new therapeutic agents targeting potassium channels.
• Academic & Institutional Studies: Utilized in university and institutional labs for fundamental research in cellular signaling and electrophysiology.
• Biochemical Assay Development: Acts as a control substance in developing and validating high-throughput screening (HTS) assays for ion channel targets.

Basic Information

Product Name	Emakalim
CAS No.	129729-66-4
Molecular Formula	C13H17ClN2O3S
Molecular Weight	316.80 g/mol
Synonyms	Emakalim; BRL-38227; (3S,4R)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile; 6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran; Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-
EINECS	Contact for details

Quality Control

Our Emakalim is produced under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for research chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.