Description

3,5-Difluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in introducing the difluorobenzoyl moiety, which can significantly alter the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and fine chemicals where fluorine substitution is strategically advantageous.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a difluorophenyl ketone or amide linkage.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluoro motif enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing mesogens used in display technologies.
• Polymer Chemistry: Employed as a monomer or modifier to introduce aromatic fluorinated units into polymer chains, improving material properties.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation, amide coupling, esterification, and other nucleophilic substitution reactions.
• Chemical Research & Development: Vital for medicinal chemistry programs exploring structure-activity relationships (SAR) through fluorination.

Basic Information

Product Name	3,5-Difluorobenzoyl Chloride
CAS No.	129714-97-2
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	3,5-Difluorobenzoyl chloride; Benzoyl chloride, 3,5-difluoro-; 3,5-Difluorobenzoic acid chloride; m,m-Difluorobenzoyl chloride; 3,5-Difluorobenzoic acid chloride; 129714-97-2; 3,5-Difluorobenzoylchloride
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global B2B clients. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.