Description

2',5'-Cyclic Methylphosphonate Guanosine is a chemically modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. Its unique cyclic phosphonate structure makes it a valuable intermediate for probing enzyme mechanisms and designing novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies focused on antiviral drug discovery, nucleotide biochemistry, and the synthesis of modified oligonucleotides.

Application

• Biochemical Research: Used as a key intermediate or reference standard in studies of nucleotide metabolism, enzyme kinetics, and polymerase function.
• Antiviral Drug Discovery: Serves as a precursor or analog in the development of nucleoside-based antiviral compounds targeting viral polymerases.
• Proteomics & Molecular Biology: Employed in the synthesis of affinity probes, enzyme inhibitors, or labeled nucleotides for studying protein-nucleic acid interactions.
• Pharmaceutical Intermediates: Acts as a critical building block in the multi-step synthesis of potential therapeutic agents and diagnostic tools.
• Enzyme Mechanism Studies: Utilized to investigate the catalytic mechanisms of phosphotransferases and other nucleotide-processing enzymes due to its modified backbone.

Basic Information

Product Name	2',5'-Cyclic Methylphosphonate Guanosine
CAS No.	129546-31-2
Molecular Formula	C11H14N5O7P
Molecular Weight	359.23 g/mol
Synonyms	2',5'-cGMP Methylphosphonate; Guanosine 2',5'-cyclic methylphosphonate; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-methylphosphonatooxolanyl]-6,9-dihydro-1H-purin-6-one; cGMP Methylphosphonate; Cyclic Guanosine Methylphosphonate; 2',5'-cGMP MeP; 2',5'-Cyclic GMP Methylphosphonate
EINECS	Contact for details

Quality Control

Our 2',5'-Cyclic Methylphosphonate Guanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.