Description

2'-Deoxy-2'-Methylidene-5-Fluorocytidine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics. It is primarily needed by research institutions, pharmaceutical companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleoside-based drugs targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel antiviral and anticancer prodrugs.
• Antiviral Drug Research: Investigated for its potential activity against a range of DNA viruses, including hepatitis B virus (HBV).
• Oncology Research: Studied for its cytostatic properties and potential incorporation into chemotherapeutic agents targeting rapidly dividing cells.
• Biochemical Research: Used in studies of nucleoside metabolism, DNA/RNA synthesis inhibition, and enzyme kinetics.
• Process Development: Employed by process chemists for route scouting, optimization, and scale-up of nucleoside analog APIs.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-Deoxy-2'-Methylidene-5-Fluorocytidine
CAS No.	129531-96-0
Molecular Formula	C10H11FN4O4
Molecular Weight	270.22 g/mol
Synonyms	2'-Deoxy-2'-methylidene-5-fluorocytidine; 5-Fluoro-2'-deoxy-2'-methylidenecytidine; 2'-Methylidene-5-fluorocytidine; 2'-Deoxy-2'-methylene-5-fluorocytidine; 5-Fluoro-2'-deoxy-2'-methylenecytidine; 2'-C-β-Methyl-2'-deoxy-5-fluorocytidine; 2'-Methylene-5-fluorocytidine; 5-Fluoro-2'-methylenecytidine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Methylidene-5-Fluorocytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.