Description

2'-Deoxy-3'-Deoxy-3'-Fluoro-5'-o-(4-Phenylbenzoyl)-Thymidine is a sophisticated nucleoside derivative, a key intermediate in the synthesis of modified oligonucleotides and potential antiviral agents. Its value lies in its precise chemical structure, which incorporates a fluorine atom and a protecting group, enabling targeted research into nucleic acid chemistry and therapeutic development. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on antisense technology, prodrug development, and exploring novel mechanisms of action against viral targets.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of fluorinated nucleoside analogs and prodrugs with potential antiviral or anticancer activity.
• Antisense Oligonucleotide Research: Used in the development of modified oligonucleotides for gene silencing and therapeutic applications, where the fluorine substitution can enhance stability and binding affinity.
• Biochemical Probe Development: Serves as a precursor for creating labeled or tagged nucleotides used to study enzyme mechanisms, such as those of polymerases and nucleases.
• Medicinal Chemistry & SAR Studies: A valuable tool for structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of nucleoside-based drug candidates.
• Academic & Contract Research: Employed in fundamental research exploring novel nucleic acid chemistries and the biological impact of specific atomic substitutions.

Basic Information

Product Name	2'-Deoxy-3'-Deoxy-3'-Fluoro-5'-o-(4-Phenylbenzoyl)-Thymidine
CAS No.	129468-53-7
Molecular Formula	C29H25FN2O7
Molecular Weight	532.52 g/mol
Synonyms	3'-Deoxy-3'-fluorothymidine 5'-(4-phenylbenzoate); 5'-O-(4-Phenylbenzoyl)-3'-deoxy-3'-fluorothymidine; 3'-Fluoro-3'-deoxythymidine 5'-(4-phenylbenzoate); 3'-F-3'-dT 5'-p-biphenylcarboxylate; 1-[(2R,4S,5R)-4-Fluoro-5-[(4-phenylbenzoyl)oxy]methyl]tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione; 3'-Fluoro-5'-O-(4-phenylbenzoyl)-2',3'-dideoxythymidine; FLT 5'-(4-Phenylbenzoate); Thymidine, 3'-deoxy-3'-fluoro-, 5'-(4-phenylbenzoate)
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxy-3'-Deoxy-3'-Fluoro-5'-o-(4-Phenylbenzoyl)-Thymidine is manufactured and tested under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.