Description

3B,4B,7A,12A-Tetrahydroxy-5B-Cholanoic Acid is a high-purity, multi-hydroxylated bile acid derivative, a critical intermediate in the synthesis of advanced pharmaceutical compounds. Its precise stereochemistry and functional group arrangement make it invaluable for research and development in metabolic and liver-related therapeutics. This compound is essential for pharmaceutical manufacturers, academic research institutions, and biotechnology companies focused on hepatology, gastroenterology, and novel drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of ursodeoxycholic acid (UDCA) analogs and other therapeutic bile acids.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid metabolism, liver function, and cholestatic diseases.
• Drug Discovery: Serves as a precursor in the development of new drug candidates targeting nuclear receptors like FXR (Farnesoid X receptor).
• Cell Culture & Diagnostics: Employed in specialized cell culture media and as a component in diagnostic assay development for liver function panels.
• Metabolic Pathway Studies: Utilized to investigate the enterohepatic circulation and the role of hydroxylated bile acids in lipid digestion and absorption.

Basic Information

Product Name	3B,4B,7A,12A-Tetrahydroxy-5B-Cholanoic Acid
CAS No.	129099-70-3
Molecular Formula	C₂₄H₄₀O₆
Molecular Weight	424.57 g/mol
Synonyms	3β,4β,7α,12α-Tetrahydroxy-5β-cholan-24-oic Acid; 3β,4β,7α,12α-Tetrahydroxy-5β-cholanoic Acid; Tetrahydroxycholanoic Acid; 5β-Cholanoic acid-3β,4β,7α,12α-tetrol; 3β,4β,7α,12α-Tetrahydroxycholanic Acid
EINECS	Contact for details

Quality Control

Our 3B,4B,7A,12A-Tetrahydroxy-5B-Cholanoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.