Description

3'-Azido-2',3'-Dideoxy-5'-o-((1,4-Dihydro-1-Methyl-3-Pyridyl)Carbonyl)Uridine is a specialized nucleoside analog derivative, a key building block in advanced pharmaceutical research and development. Its value lies in its unique azido and dihydro-nicotinamide functional groups, which are critical for probing biochemical pathways and developing novel therapeutic agents. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a probe or substrate in enzymatic studies to investigate mechanisms of action for nucleotide-metabolizing enzymes.
• Prodrug Development: The dihydronicotinamide moiety can be utilized in prodrug strategies for targeted drug delivery and activation.
• Antiviral Agent Synthesis: A key starting material for the development of dideoxynucleoside analogs, a class known for activity against retroviruses.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside therapeutics.
• Labeled Compound Synthesis: The azido group provides a handle for "click chemistry" applications, enabling the creation of fluorescently tagged or bioconjugated molecules for diagnostic and research purposes.

Basic Information

Product Name	3'-Azido-2',3'-Dideoxy-5'-o-((1,4-Dihydro-1-Methyl-3-Pyridyl)Carbonyl)Uridine
CAS No.	128526-53-4
Molecular Formula	C16H18N6O6
Molecular Weight	390.35 g/mol
Synonyms	3'-Azido-2',3'-dideoxy-5'-O-[1-methyl-1,4-dihydro-3-pyridinecarbonyl]uridine; 5'-O-(1-Methyl-1,4-dihydronicotinoyl)-3'-azido-2',3'-dideoxyuridine; 3'-Azido-3'-deoxy-5'-O-(1-methyl-1,4-dihydronicotinoyl)thymidine precursor; AZT Nicotinamide Ester Derivative; Uridine, 3'-azido-2',3'-dideoxy-5'-O-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyl]-; Dihydronicotinamide AZT Prodrug Intermediate
EINECS	Contact for details

Quality Control

Our 3'-Azido-2',3'-Dideoxy-5'-o-((1,4-Dihydro-1-Methyl-3-Pyridyl)Carbonyl)Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee compliance with your research and cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.