Description

3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is a high-purity, protected nucleoside derivative that serves as a critical building block in oligonucleotide synthesis. This compound is essential for the development of antisense oligonucleotides and other therapeutic nucleic acids, where precise chemical modification is required for stability and efficacy. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CDMOs specializing in advanced nucleic acid therapeutics.

Application

• Key Intermediate for Antisense Oligonucleotide (ASO) Synthesis: Used in the solid-phase or solution-phase synthesis of therapeutic oligonucleotides targeting genetic diseases.
• Building Block for siRNA and miRNA: Enables the incorporation of 2'-fluoro modifications to enhance nuclease resistance and binding affinity in RNA-based therapeutics.
• Research and Development of Novel Therapeutics: Employed in academic and industrial labs for developing new nucleic acid drugs, including aptamers and gene silencing agents.
• Process Development and Scale-Up: Serves as a critical raw material for contract development and manufacturing organizations (CDMOs) scaling up GMP production of oligonucleotide APIs.
• Diagnostic Probe Synthesis: Used in the manufacture of labeled probes for molecular diagnostics and research assays requiring high specificity.

Basic Information

Product Name	3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine
CAS No.	128496-10-6
Molecular Formula	C25H21FN2O7
Molecular Weight	480.45 g/mol
Synonyms	2'-Deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinouridine; 2'-Fluoro-2'-deoxy-3',5'-di-O-benzoyl-β-D-arabinouridine; 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinouridine; 2'-F-araU(Bz)2; 2'-F-Bz-araU; 1-[(2R,3S,4R,5R)-3,4-Bis(benzoyloxy)-5-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; Protected 2'-F-araU Nucleoside
EINECS	Contact for details

Quality Control

Our 3',5'-Bis-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for advanced pharmaceutical intermediates, ensuring reliable supply and consistent quality for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.