Description

2-Hydroxypropyl-β-Cyclodextrin is a chemically modified, water-soluble derivative of β-cyclodextrin, widely recognized for its superior solubilizing and stabilizing properties. This compound is essential for enhancing the bioavailability and stability of poorly soluble active ingredients in aqueous formulations. It is a critical excipient for pharmaceutical manufacturers, research institutions, and companies in the nutraceutical and cosmetic industries seeking advanced delivery solutions.

Application

• Pharmaceutical Solubilizer & Stabilizer: Enhances the aqueous solubility and stability of hydrophobic drugs in injectable, oral, and topical formulations.
• Drug Delivery Systems: Used to form inclusion complexes for controlled release, taste masking, and bioavailability improvement of APIs.
• Biotechnology & Research: Serves as a chiral selector in chromatography and a stabilizing agent for proteins, enzymes, and labile compounds in biochemical assays.
• Nutraceuticals & Cosmetics: Improves the solubility and delivery of vitamins, flavors, fragrances, and active cosmetic ingredients.
• Analytical Chemistry: Employed as an additive in capillary electrophoresis and other separation techniques to improve resolution.
• Chemical Synthesis: Acts as a green, recyclable catalyst or reaction medium in various organic synthesis processes.

Basic Information

Product Name	2-Hydroxypropyl-β-Cyclodextrin
CAS No.	128446-35-5
Molecular Formula	C42H70O35 · (C3H6O)n
Molecular Weight	~1135 g/mol (base) + substitution-dependent
Synonyms	HP-β-CD; Hydroxypropyl Beta Cyclodextrin; (2-Hydroxypropyl)-β-cyclodextrin; Heptakis(2-hydroxypropyl)-β-cyclodextrin; β-Cyclodextrin, 2-hydroxypropyl ether; Kleptose® HPB; Cavasol® W7 HP; Encapsin® HPB; Hydroxypropylbetadex (Ph. Eur.)
EINECS	Contact for details

Quality Control

Our 2-Hydroxypropyl-β-Cyclodextrin is manufactured under a strict quality management system. It is available in various grades, including Pharmaceutical (USP/Ph. Eur.) and high-purity research grades. Each batch undergoes rigorous analytical testing to ensure compliance with specified parameters for identity, purity, substitution degree, and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed after initial use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-β-CD Content)	≥ 98.0% (on dried basis)
Degree of Substitution (Molar)	0.6 - 1.0 (or as specified)
Water Content (Karl Fischer)	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Microbial Limits	Conforms to Ph. Eur./USP
pH (10% Solution)	5.0 - 7.5
Specific Rotation	+130° to +145°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.