Description

5-Carboxyethyl-3'-Azido-3'-Deoxythymidine is a high-purity nucleoside analog derivative, a critical building block in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate in the creation of novel antiviral and anticancer agents, particularly in the development of nucleoside reverse transcriptase inhibitors. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on innovative therapeutic solutions.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral drugs, including potential HIV and hepatitis therapeutics.
• Anticancer Agent Research: Serves as a building block for developing prodrugs and targeted cancer therapies that exploit nucleoside metabolism.
• Biochemical Probe Development: Used in medicinal chemistry to study enzyme mechanisms and for the design of activity-based probes targeting viral polymerases.
• Organic Synthesis: Employed in sophisticated multi-step organic syntheses requiring a functionalized thymidine derivative with both azido and carboxyethyl groups for click chemistry or further conjugation.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research on nucleic acid chemistry and drug discovery pathways.

Basic Information

Product Name	5-Carboxyethyl-3'-Azido-3'-Deoxythymidine
CAS No.	128439-97-4
Molecular Formula	C13H17N5O6
Molecular Weight	339.30 g/mol
Synonyms	3'-Azido-3'-deoxy-5-carboxyethylthymidine; 5-(2-Carboxyethyl)-3'-azido-3'-deoxythymidine; 3'-Azido-2',3'-dideoxy-5-(2-carboxyethyl)uridine; AZT Carboxyethyl Derivative; 5-Carboxyethyl AZT; 1-[(2R,4S,5R)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-(2-carboxyethyl)pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-Carboxyethyl-3'-Azido-3'-Deoxythymidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.