Description

5'-o-Dmt-2'-o-Methyl-N6-Phenoxyacetyl-D-Adenosine is a high-purity, chemically modified nucleoside derivative, specifically engineered for oligonucleotide synthesis. This compound is a critical building block in the production of antisense oligonucleotides and other therapeutic nucleic acids, where it provides enhanced nuclease resistance and improved pharmacokinetic properties. It is an essential raw material for pharmaceutical R&D and manufacturing, particularly for companies developing advanced RNA-based therapeutics and diagnostics.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of therapeutic oligonucleotides.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate 2'-O-methyl modifications, which are crucial for enhancing target binding affinity and metabolic stability of ASO drugs.
• siRNA and miRNA Therapeutics: Serves as a modified monomer for constructing strands with improved silencing activity and reduced off-target effects.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled probes and primers for sensitive molecular diagnostics and research assays.
• Pharmaceutical Intermediate: Acts as a vital intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Academic and Contract Research: Utilized in research laboratories for studying RNA structure, function, and for developing novel nucleic acid technologies.

Basic Information

Product Name	5'-o-Dmt-2'-o-Methyl-N6-Phenoxyacetyl-D-Adenosine
CAS No.	128219-81-8
Molecular Formula	C39H41N5O8
Molecular Weight	707.78 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-phenoxyacetyladenosine; DMT-2'-O-Me-N6-Pac-Adenosine; 2'-O-Methyl-5'-O-DMT-N6-Pac-adenosine; 2'-O-Methyl-5'-O-(4,4'-dimethoxytrityl)-N6-(phenoxyacetyl)adenosine; N6-Phenoxyacetyl-2'-O-methyl-5'-O-DMT-adenosine; 2'-O-Methyl-N6-phenoxyacetyl-5'-O-DMT-adenosine; Protected 2'-O-Methyladenosine Derivative; D-Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-[2-(phenoxy)acetyl]-
EINECS	Contact for details

Quality Control

Every batch of 5'-o-Dmt-2'-o-Methyl-N6-Phenoxyacetyl-D-Adenosine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider storage at -20°C under nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.