Description

2'-O-Methyl-N6-Phenoxyacetyladenosine is a chemically modified nucleoside derivative, specifically engineered for advanced research and development applications. This compound is a critical building block in oligonucleotide synthesis, particularly for the creation of antisense oligonucleotides and siRNA, where it enhances stability and binding affinity. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions focused on nucleic acid therapeutics, diagnostics, and molecular biology.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of modified RNA strands, improving nuclease resistance and pharmacokinetic properties.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific mRNA sequences for therapeutic intervention.
• siRNA and miRNA Research: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) constructs to increase stability and efficacy in gene silencing applications.
• Diagnostic Probe Development: Serves as a modified component in the creation of high-specificity probes for nucleic acid detection and hybridization assays.
• Biochemical Research: Employed as a tool compound to study RNA structure, function, and protein-RNA interactions.
• Pharmaceutical Intermediates: Acts as a sophisticated intermediate in the multistep synthesis of novel nucleoside-based drug candidates.

Basic Information

Product Name	2'-O-Methyl-N6-Phenoxyacetyladenosine
CAS No.	128219-80-7
Molecular Formula	C19H21N5O6
Molecular Weight	415.40 g/mol
Synonyms	N6-Phenoxyacetyl-2'-O-methyladenosine; 2'-O-Methyladenosine, N6-(phenoxyacetyl)-; 6-(Phenoxyacetamido)-9-β-D-ribofuranosylpurine, 2'-O-methyl-; 2'-O-Me-N6-Pac-Ado; 2'-OMe-N6-Pac-A; Adenosine, N6-(phenoxyacetyl)-2'-O-methyl-; 2'-O-Methyl-N6-pac-adenosine
EINECS	Contact for details

Quality Control

Every batch of 2'-O-Methyl-N6-Phenoxyacetyladenosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR and MS), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.