Description

Cyclopropanecarbonyl Chloride, 2,2-Difluoro-1-Methyl- (9Ci) is a high-purity, reactive organofluorine building block essential for advanced chemical synthesis. Its unique difluorocyclopropane structure makes it a critical intermediate for introducing fluorinated motifs, which are key to modulating the physical and biological properties of target molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluorocyclopropane unit can enhance stability and bioavailability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials that require fluorinated components for improved chemical resistance or surface properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex, fluorinated organic molecules via reactions such as nucleophilic substitution and Friedel-Crafts acylation.
• Ligand and Catalyst Development: Useful for creating novel fluorinated ligands for catalysis or as a modifying agent for catalyst surfaces in fine chemical manufacturing.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2,2-Difluoro-1-Methyl- (9Ci)
CAS No.	128146-92-9
Molecular Formula	C5H5ClF2O
Molecular Weight	154.54 g/mol
Synonyms	2,2-Difluoro-1-methylcyclopropanecarbonyl chloride; 1-Methyl-2,2-difluorocyclopropanecarboxylic acid chloride; 2,2-Difluoro-1-methylcyclopropanecarboxylic acid chloride; 2,2-Difluoro-1-methylcyclopropanecarbonyl chloride; 1-Methyl-2,2-difluorocyclopropanecarbonyl chloride; (2,2-Difluoro-1-methylcyclopropyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 2,2-Difluoro-1-Methyl- (9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our commitment to cGMP principles and relevant ICH guidelines ensures the material meets the stringent requirements of pharmaceutical and advanced chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive acid chloride nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.