Description

2-Pyridinecarbonyl Chloride, 5-Methyl- (9Ci) is a versatile and reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 5-methylpicolinoyl moiety, enabling the construction of complex molecules with high precision. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require a reliable, high-purity reagent for amide and ester formation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand and Catalyst Preparation: Acts as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to functionalize polymers, imparting specific chemical properties for advanced material applications.
• Peptide Mimetics & Bio-conjugation: Facilitates the synthesis of peptide analogs and is used in linker chemistry for antibody-drug conjugates (ADCs).
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new chemical entities and reaction methodologies.

Basic Information

Item	Details
Product Name	2-Pyridinecarbonyl Chloride, 5-Methyl- (9Ci)
CAS No.	128073-07-4
Molecular Formula	C7H6ClNO
Molecular Weight	155.58 g/mol
Synonyms	5-Methylpicolinoyl chloride; 5-Methylpyridine-2-carbonyl chloride; 2-Carbonyl chloride-5-methylpyridine; 5-Methyl-2-pyridinecarboxylic acid chloride; 5-Methylpicolinic acid chloride; 5-Methylpyridine-2-carboxylic acid chloride; 2-Pyridinecarbonyl chloride, 5-methyl-
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridinecarbonyl Chloride, 5-Methyl- is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity and traceability. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all commercial quantities, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and reactive nature. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.