Description

2-Pyridinecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci) is a high-value, reactive chemical intermediate featuring a trifluoromethylated pyridine core. This compound matters for its role as a key building block in the synthesis of complex molecules, where the introduction of the trifluoromethyl group and the acid chloride functionality are critical for downstream modifications. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require specific fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci)
CAS No.	128073-05-2
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	5-(Trifluoromethyl)picolinoyl chloride; 5-(Trifluoromethyl)pyridine-2-carbonyl chloride; 2-Pyridinecarbonyl chloride, 5-(trifluoromethyl)-; 5-Trifluoromethylpicolinic acid chloride; 5-Trifluoromethyl-2-pyridinecarboxylic acid chloride; 5-Trifluoromethyl-2-picolinoyl chloride; α-Chloro-5-(trifluoromethyl)picolinaldehyde (tautomer); 5-(Trifluoromethyl)-2-pyridylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.