Description

2-Pyridinecarbonyl Chloride, 3-(Trifluoromethyl)- (9Ci) is a high-value, multi-functional chemical building block characterized by its reactive acid chloride group and electron-withdrawing trifluoromethyl substituent. This compound matters for its critical role in synthesizing complex molecules, particularly in the development of advanced pharmaceuticals and agrochemicals where the CF3 group imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing pyridine-based amides, esters, and other derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the pyridine and trifluoromethyl motifs are prevalent.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of novel organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Bioconjugation and Probe Development: Useful for modifying biomolecules or creating fluorescent probes and other diagnostic tools in life science research.

Basic Information

Item	Details
Product Name	2-Pyridinecarbonyl Chloride, 3-(Trifluoromethyl)- (9Ci)
CAS No.	128073-04-1
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	3-(Trifluoromethyl)picolinoyl chloride; 3-(Trifluoromethyl)pyridine-2-carbonyl chloride; 2-Pyridinecarbonyl chloride, 3-(trifluoromethyl)-; 3-Trifluoromethylpicolinic acid chloride; 3-Trifluoromethyl-2-pyridinecarboxylic acid chloride; 3-CF3-Picolinoyl chloride; 2-Carboxy-3-trifluoromethylpyridine chloride
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonyl Chloride, 3-(Trifluoromethyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.