Description

2-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci) is a versatile and highly reactive acid chloride derivative of a chlorinated pyridine, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 5-chloro-2-pyridinecarbonyl moiety, a key structural feature in the development of active pharmaceutical ingredients and functional materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system or possessing antimicrobial properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloropyridine scaffold contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel pyridine-based ligands used in transition metal catalysis and coordination chemistry.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or molecular sensors.
• Peptide Mimetics and Bioconjugation: Useful for acylating amines in the creation of peptide analogs or for modifying biomolecules in bioconjugation strategies.
• Custom Synthesis and R&D: A valuable reagent for contract research organizations (CROs) and academic labs exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci)
CAS No.	128073-03-0
Molecular Formula	C6H3Cl2NO
Molecular Weight	176.00 g/mol
Synonyms	5-Chloropicolinoyl chloride; 5-Chloro-2-pyridinecarbonyl chloride; 5-Chloropyridine-2-carbonyl chloride; 2-Pyridinecarbonyl chloride, 5-chloro-; 5-Chloropicolinic acid chloride; 5-Chloro-2-carboxypyridine chloride; Picolinoyl chloride, 5-chloro-
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci) undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.