Description

Z-2-Nal-Chloromethylketone is a specialized organic building block featuring a naphthylalanine-derived structure with a reactive chloromethyl ketone group. This compound is critical for the synthesis of targeted covalent inhibitors and other bioactive molecules, offering researchers precise control over molecular interactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of protease inhibitors and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of covalent protease inhibitors, particularly targeting serine and cysteine proteases.
• Biochemical Research: Used as an active site-directed affinity label for studying enzyme mechanisms and protein function.
• Peptidomimetic Development: Serves as a core scaffold for creating stable, bioactive peptide analogs with enhanced pharmacological properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize inhibitor potency and selectivity.
• Chemical Biology Probes: Facilitates the creation of activity-based probes (ABPs) for profiling enzyme activities in complex biological systems.

Basic Information

Product Name	Z-2-Nal-Chloromethylketone
CAS No.	128019-71-6
Molecular Formula	C22H22ClNO4
Molecular Weight	399.87 g/mol
Synonyms	N-(Benzyloxycarbonyl)-3-(2-naphthyl)-D-alanyl Chloromethyl Ketone; Z-2-Nal-CMK; Z-D-2-Naphthylalanine Chloromethyl Ketone; Z-3-(2-Naphthyl)-D-alanine Chloromethyl Ketone; N-CBZ-3-(2-Naphthyl)-D-alanyl Chloromethyl Ketone; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(naphthalen-2-yl)propyl Chloromethyl Ketone; Nα-Carbobenzoxy-3-(2-naphthyl)-D-alanyl Chloromethyl Ketone
EINECS	Contact for details

Quality Control

Our Z-2-Nal-Chloromethylketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.