Description

(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol is a high-value chiral intermediate characterized by its phenyl ethanol core flanked by two trifluoromethyl groups. This compound matters as a critical building block in modern asymmetric synthesis, where its defined stereochemistry and fluorine-rich aromatic system enable the development of advanced pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Key chiral intermediate in the synthesis of pharmaceutical active ingredients, particularly for central nervous system (CNS) and antiviral drugs.
• Building block for asymmetric catalysts and ligands used in enantioselective transformations.
• Precursor in the development of agrochemicals, such as advanced herbicides and fungicides, leveraging the properties of the trifluoromethyl groups.
• Intermediate for material science applications, including the synthesis of specialty monomers for fluorinated polymers.
• Starting material for tracer molecules and diagnostic agents in medical research.
• Reference standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol
CAS No.	127852-28-2
Molecular Formula	C10H8F6O
Molecular Weight	258.16 g/mol
Synonyms	(R)-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-ol; (R)-α-(3,5-Bis(trifluoromethyl)phenyl)ethyl alcohol; (R)-3,5-Bis(trifluoromethyl)benzeneethanol; (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol; (R)-BTMPE; (R)-1-(3,5-Di(trifluoromethyl)phenyl)ethanol
EINECS	Contact for details

Quality Control

Our (R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.