Description

5-Chloro-2',3'-Dideoxyuridine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and a key intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and DNA replication. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Research: Used in the development of compounds targeting viral polymerases, such as those of HIV and hepatitis viruses.
• Oncology Research: Serves as a scaffold for creating potential chemotherapeutic agents that interfere with DNA synthesis in cancer cells.
• Biochemical Research: Employed as a tool compound in enzymatic studies and to investigate nucleoside metabolism and transport.
• Fine Chemical Synthesis: Utilized in custom synthesis and the production of specialized, high-value chemical entities for research purposes.

Basic Information

Product Name	5-Chloro-2',3'-Dideoxyuridine
CAS No.	127592-40-9
Molecular Formula	C9H11ClN2O4
Molecular Weight	246.65 g/mol
Synonyms	5-Chloro-2',3'-dideoxyuridine; 5-Chloro-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2',3'-Dideoxy-5-chlorouridine; 5-Cl-ddU; 5-Chloro-ddU; 5-Chloro-2',3'-ddU; 5-Chloro-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Chloro-2',3'-Dideoxyuridine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.