Description

1-((2-Azido-1-(Hydroxymethyl)Ethoxy)Methyl)Thymine is a specialized nucleoside analog derivative, primarily valued for its role as a key synthetic intermediate in the development of novel pharmaceuticals and advanced research compounds. Its unique structure, featuring an azido functional group, makes it a critical building block for click chemistry applications, enabling the efficient synthesis of complex biomolecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors focused on antiviral drug discovery, oligonucleotide synthesis, and probe development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and labeling of biomolecules.
• Oligonucleotide Synthesis: Serves as a modified thymidine monomer for creating functionalized DNA/RNA strands for diagnostic and therapeutic applications.
• Biochemical Probe Development: Used to create tagged nucleotides for studying cellular processes, enzyme mechanisms, and nucleic acid interactions.
• Antiviral Research: Investigated as a building block for prodrugs targeting viral polymerases in diseases such as HIV and hepatitis.
• Polymer Science: Incorporated into functional polymers and hydrogels for biomedical and material science applications.

Basic Information

Product Name	1-((2-Azido-1-(Hydroxymethyl)Ethoxy)Methyl)Thymine
CAS No.	127559-73-3
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	3-((2-Azido-1-(hydroxymethyl)ethoxy)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[(2-Azido-1-hydroxymethylethoxy)methyl]thymine; Azidomethyl Hydroxyethyl Thymine; 5'-Azido-5'-deoxythymidine derivative; N3-((2-Azido-1-(hydroxymethyl)ethoxy)methyl)thymine; AZT Hydroxyethyl Derivative; Thymine azido ether
EINECS	Contact for details

Quality Control

Our 1-((2-Azido-1-(Hydroxymethyl)Ethoxy)Methyl)Thymine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of advanced synthetic chemistry and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccants and temperature monitoring.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.