Description

1H-Indole-1-Carbonyl Chloride (9Ci) is a versatile and highly reactive organic building block, primarily used as a key intermediate in advanced organic synthesis. Its value lies in its ability to efficiently introduce the indole-1-carbonyl moiety, a crucial step in constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides with specific modes of action.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and organic electronic materials.
• Peptide & Protein Modification: Employed as a coupling reagent or for introducing specific labels into biomolecules for research and diagnostic applications.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex heterocyclic dyes and high-performance pigments.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	1H-Indole-1-Carbonyl Chloride (9Ci)
CAS No.	127485-48-7
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	1H-Indole-1-carbonyl chloride; Indole-1-carbonyl chloride; 1-Carboxyindole chloride; 1-Indolecarbonyl chloride; 1H-Indole-1-carboxylic acid chloride; 1-Indolylcarbonyl chloride; NSC 405124; 1-Carboxy-1H-indole chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carbonyl Chloride is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. A Certificate of Analysis (COA) detailing specific results for purity, identity, and related substances is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.