Description

Benzoic Acid, 4-(Fluorocarbonyl)- (9Ci) is a specialized fluorinated benzoic acid derivative, serving as a high-value building block in advanced organic synthesis. Its core value lies in the introduction of both a carboxylic acid and a highly reactive carbonyl fluoride group onto an aromatic ring, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating specialized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Building block for novel herbicides and fungicides where the fluorine atom enhances biological activity and environmental stability.
• Polymer Chemistry: Monomer for synthesizing specialty polyesters and polyamides with unique thermal and chemical resistance properties.
• Liquid Crystal Materials: Used in the development of fluorinated liquid crystal compounds for advanced display technologies.
• Cross-coupling Reactions: Serves as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetics: The carbonyl fluoride group is utilized for efficient amide bond formation in peptide analog synthesis.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and creating custom fluorinated scaffolds.

Basic Information

Product Name	Benzoic Acid, 4-(Fluorocarbonyl)- (9Ci)
CAS No.	127410-75-7
Molecular Formula	C8H5FO3
Molecular Weight	168.12 g/mol
Synonyms	4-(Fluorocarbonyl)benzoic acid; Terephthalic acid monofluoride; 4-Carboxybenzoyl fluoride; Monofluorocarbonyl terephthalic acid; 4-Fluorocarbonylbenzoic acid; p-(Fluorocarbonyl)benzoic acid; 4-Carboxybenzoyl fluoride; Benzoic acid, p-(fluorocarbonyl)-
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-(Fluorocarbonyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and FTIR to confirm identity and purity, ensuring it meets the exacting standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your internal quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis of the reactive carbonyl fluoride group. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.