Description

Linarotene CAS NO 127304-28-3 is a synthetic retinoid derivative, a class of compounds known for their potent biological activity in regulating cell growth and differentiation. This compound is valued for its high purity and consistent quality, making it a critical intermediate for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents for dermatological and oncological applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel retinoid-based drugs targeting skin disorders and cancers.
• Biochemical Research: Used as a reference standard or active agent in studies investigating retinoid receptor (RAR/RXR) pathways and gene expression.
• Dermatology R&D: Applied in preclinical research for developing topical or systemic treatments for conditions like acne, psoriasis, and photoaging.
• Oncology Research: Investigated for its potential chemopreventive and therapeutic effects in various cancer cell line studies.
• API Development: Employed as a starting material or intermediate in the process development and scale-up of Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Linarotene
CAS No.	127304-28-3
Molecular Formula	C23H28O2
Molecular Weight	336.47 g/mol
Synonyms	AGN 190168; AGN-190168; 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid; 4-[1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)vinyl]benzoic Acid; Linarotene [USAN]; Retinoid AGN 190168; Tazarotene-related compound A
EINECS	Contact for details

Quality Control

Our Linarotene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.