Description

N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-Methyl Adenosine is a sophisticated, high-purity nucleoside derivative specifically designed for advanced oligonucleotide synthesis. This compound serves as a critical, protected building block, enabling the precise and efficient assembly of DNA and RNA sequences. It is an essential raw material for research institutions, diagnostic developers, and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, aptamers, and other therapeutic nucleic acids.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of modified DNA/RNA strands.
• Therapeutic Nucleic Acid Development: Used in the research and production of antisense drugs, siRNA therapeutics, and aptamers targeting various diseases.
• Diagnostic Probe Synthesis: Manufacture of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH) applications.
• Chemical Biology Research: A valuable tool for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Synthesis of Modified Nucleosides: Intermediate for further chemical modifications to create novel nucleoside analogs with tailored properties.

Basic Information

Product Name	N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-Methyl Adenosine
CAS No.	127212-38-8
Molecular Formula	C39H37N5O7
Molecular Weight	687.75 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-3'-O-methyladenosine; 3'-O-Methyl-N6-benzoyl-5'-O-DMT-adenosine; DMT-rA(Bz)-3'-OMe; N6-Benzoyl-3'-O-methyl-5'-O-(4,4'-dimethoxytrityl)adenosine; 3'-O-Methyl-5'-O-DMT-N6-benzoyladenosine; Adenosine, N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-; Protected 3'-O-Methyladenosine Derivative
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-5'-o-(4,4'-Dimethoxytrityl)-3'-o-Methyl Adenosine is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.