Description

Inosine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-[(1,1-Dimethylethyl)Dimethylsilyl]- is a sophisticated, protected nucleoside derivative crucial for advanced oligonucleotide synthesis. This compound matters because it serves as a key building block, or phosphoramidite precursor, enabling the precise construction of RNA and DNA sequences for research and therapeutic applications. Pharmaceutical R&D laboratories, biotechnology companies, and academic institutions specializing in antisense technology, siRNA, and aptamer development are the primary users of this high-purity intermediate.

Application

• Solid-Phase Oligonucleotide Synthesis: As a critical phosphoramidite precursor for the automated synthesis of modified RNA strands.
• Antisense & siRNA Therapeutic Development: Used in creating research-grade and potential therapeutic oligonucleotides targeting specific genes.
• Aptamer and Diagnostic Probe Construction: Enables the incorporation of inosine bases, which can pair with multiple nucleotides, into probes for binding studies and diagnostic assays.
• Structural Biology & NMR Studies: Acts as a selectively protected intermediate for preparing isotopically labeled nucleosides used in biomolecular structure determination.
• Medicinal Chemistry Research: Serves as a starting material for the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.

Basic Information

Product Name	Inosine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	127212-34-4
Molecular Formula	C39H48N4O7Si
Molecular Weight	712.91 g/mol
Synonyms	5'-O-DMT-2'-O-TBDMS-inosine; 2'-O-TBDMS-5'-O-DMT-inosine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)inosine; DMT-Inosine(TBDMS); N-DMT-2'-O-TBDMS-inosine; Inosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; Protected Inosine Derivative
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols in dedicated facilities. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality management system supports compliance with cGMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, preferably in a dry atmosphere or sealed with desiccant. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.