Description

2,2-Difluoro-1,3-benzodioxole-5-carbonyl chloride is a high-purity, reactive chemical intermediate featuring a benzodioxole core with fluorine substitution. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring a fluorinated benzodioxole moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluorobenzodioxole structure contributes to efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, coatings, and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to construct complex ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry Building Block: Utilized as a versatile scaffold for introducing fluorine atoms and specific ring systems into target molecules in medicinal and discovery chemistry.

Basic Information

Item	Details
Product Name	2,2-Difluoro-1,3-benzodioxole-5-carbonyl Chloride
CAS No.	127163-51-3
Molecular Formula	C8H2ClF2O3
Molecular Weight	218.55 g/mol
Synonyms	5-(Chlorocarbonyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluorobenzodioxole-5-carbonyl chloride; 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid chloride; 1,3-Benzodioxole-5-carbonyl chloride, 2,2-difluoro-; 127163-51-3; Difluorobenzodioxole carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1,3-benzodioxole-5-carbonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.