Description

4-Chloro-3-Nitrophenyl Isothiocyanate is a versatile and reactive aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of electrophilic sites—the isothiocyanate group and the nitro and chloro substituents—which enable precise derivatization for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active ingredients, dyes, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing novel heterocyclic compounds with potential biological activity, including benzimidazoles and thiazoles.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its reactive sites to create targeted bioactive molecules.
• Dye and Pigment Manufacturing: Serves as a core structure for producing azo dyes and other complex colorants due to its nitro and aromatic components.
• Polymer Modification: Acts as a coupling agent or cross-linker for introducing specific functional groups into polymer chains to enhance material properties.
• Chemical Biology Research: Utilized as a probe or labeling reagent for modifying proteins and peptides, exploiting the reactivity of the isothiocyanate group with amines.
• Ligand and Catalyst Development: Building block for creating sophisticated chelating ligands used in catalysis and metal complexation.

Basic Information

Product Name	4-Chloro-3-Nitrophenyl Isothiocyanate
CAS No.	127142-66-9
Molecular Formula	C7H3ClN2O2S
Molecular Weight	214.63 g/mol
Synonyms	1-Chloro-4-isothiocyanato-2-nitrobenzene; 3-Nitro-4-chlorophenyl isothiocyanate; 4-Chloro-3-nitrobenzenisothiocyanate; 2-Nitro-4-chlorophenyl isothiocyanate; (4-Chloro-3-nitrophenyl) isothiocyanate; Isothiocyanic acid, 4-chloro-3-nitrophenyl ester; 4-Chloro-3-nitro-phenylisothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Nitrophenyl Isothiocyanate is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.