Description

2'-Dimethyl-tert-Butylsilyl-N(2)-(N,n-Dimethylamino)Methylene-Guanosine 3',5'-Cyclic Diethylphosphoramidate is a sophisticated, nucleoside-based chemical building block designed for advanced research and synthesis. This compound is critical for scientists developing novel oligonucleotide therapeutics and probes, where precise chemical modification is paramount. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions specializing in nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite monomer for the solid-phase synthesis of modified RNA and DNA strands.
• Therapeutic Development: Used in the research and production of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Probe and Diagnostic Tool Fabrication: Enables the creation of labeled or structurally modified nucleic acid probes for diagnostic assays and genomic research.
• Medicinal Chemistry Research: Acts as a crucial intermediate in exploring structure-activity relationships (SAR) for nucleoside analog drugs.
• Bioconjugation: Facilitates the site-specific attachment of guanosine derivatives to other molecules, such as peptides, fluorophores, or delivery vehicles.

Basic Information

Product Name	2'-Dimethyl-tert-Butylsilyl-N(2)-(N,n-Dimethylamino)Methylene-Guanosine 3',5'-Cyclic Diethylphosphoramidate
CAS No.	126922-65-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Guanosine, 2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-[2-[(dimethylamino)methylene]amino]-3',5'-cyclic diethylphosphoramidate; 2'-O-(tert-Butyldimethylsilyl)-N2-(dimethylaminomethylene)guanosine 3',5'-cyclic diethylphosphoramidate; 2'-TBDMS-N2-DMF-Guanosine 3',5'-Cyclic Diethylphosphoramidate; Guanosine phosphoramidite (N2-DMF protected); RNA synthesis monomer (guanosine derivative); N2-(Dimethylaminomethylene)-2'-O-(tert-butyldimethylsilyl)guanosine 3',5'-cyclic diethylphosphoramidite
EINECS	Contact for details

Quality Control

Every batch of this high-purity building block is produced and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and moisture content, ensuring compliance with the exacting standards required for pharmaceutical R&D and oligonucleotide synthesis. Our quality commitment supports your need for reproducible results and regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic nature, allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.