Description

5'-Dmt-Dmf-Rg CAS NO 126922-60-9 is a high-purity, protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound is essential for the controlled assembly of DNA and RNA sequences, ensuring high coupling efficiency and yield. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in the development of therapeutic oligonucleotides, diagnostic probes, and advanced molecular biology tools.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides, siRNA, and aptamers for targeted therapies.
• Research & Diagnostic Probe Development: Synthesis of labeled probes for genomics, PCR, and hybridization assays.
• Antisense Technology: Building block for creating modified oligonucleotides with enhanced stability and binding affinity.
• Process Development & Scale-Up: Used in pilot plants and cGMP manufacturing for clinical and commercial-scale API production.

Basic Information

Product Name	5'-Dmt-Dmf-Rg
CAS No.	126922-60-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N2-(dimethylaminomethylene)-2'-deoxyguanosine; DMT-DMF-dG; N2-(Dimethylaminomethylene)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine; Protected 2'-Deoxyguanosine Derivative; DMT-G(DMF) Amidite Precursor
EINECS	Contact for details

Quality Control

Our 5'-Dmt-Dmf-Rg is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and moisture content analysis. We provide Certificates of Analysis (COA) with detailed results to ensure traceability and compliance with your internal specifications and regulatory requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and performance in sensitive synthesis applications.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.