Description

1-Amino-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-Triazol-1-Yl)Propane-2-Ol is a high-purity, advanced pharmaceutical intermediate with a complex molecular structure featuring both difluorophenyl and triazole moieties. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the antifungal and antimicrobial therapeutic classes. It is primarily sought by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of next-generation triazole-based drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potent triazole antifungal agents.
• Antifungal Drug Development: Core scaffold in research for new systemic and topical antifungal medications targeting fungal CYP51.
• Antimicrobial Research: Used in the discovery and development of novel antimicrobial compounds with unique mechanisms of action.
• Chemical Synthesis: Serves as a versatile precursor for further chemical modifications in medicinal chemistry programs.
• Biochemical Research: Utilized as a reference standard or probe in studies of enzyme inhibition and sterol biosynthesis pathways.
• Custom Manufacturing: Supplied for contract manufacturing and development (CMO/CDMO) projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-Amino-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-Triazol-1-Yl)Propane-2-Ol
CAS No.	126916-76-5
Molecular Formula	C11H12F2N4O
Molecular Weight	254.24 g/mol
Synonyms	2-Amino-1-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol; 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1,3-propanediol, 2-Amino derivative; α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-β-aminoethanol; Fluconazole Intermediate Derivative; Difluorophenyl Triazolyl Aminopropanol
EINECS	Contact for details

Quality Control

Our 1-Amino-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-Triazol-1-Yl)Propane-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.