Description

Naltrindole Isothiocyanate is a highly selective and potent covalent antagonist for the delta opioid receptor (DOR), widely utilized as a critical pharmacological research tool. Its isothiocyanate functional group enables irreversible binding, making it invaluable for receptor isolation, mapping, and biochemical characterization studies. This compound is essential for researchers and pharmaceutical developers in neuroscience, pharmacology, and drug discovery, particularly those investigating opioid receptor function and signaling pathways.

Application

• Neuroscience Research: Irreversible labeling and isolation of delta opioid receptors (DOR) in brain tissue and cell cultures.
• Pharmacological Studies: Used as a covalent antagonist to study DOR-mediated signaling, desensitization, and internalization mechanisms.
• Biochemical Assay Development: A key reagent for developing binding assays and screening for novel DOR ligands or modulators.
• Drug Discovery: Serves as a prototype compound in the design and development of new selective opioid receptor antagonists.
• Receptor Mapping: Employed in affinity chromatography and photoaffinity labeling experiments to study receptor structure and distribution.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring pain pathways, addiction, and neuropsychiatric disorders.

Basic Information

Product Name	Naltrindole Isothiocyanate
CAS No.	126876-64-0
Molecular Formula	C₂₆H₂₅N₅O₂S
Molecular Weight	471.58 g/mol
Synonyms	17-Cyclopropylmethyl-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan Isothiocyanate; NTI Isothiocyanate; Naltrindole ITC; δ-Opioid Receptor Covalent Antagonist; 5'-Isothiocyanatonaltrindole; Naltrindole Isothiocyanate Hydrochloride (related salt); NTI-NCS
EINECS	Contact for details

Quality Control

Our Naltrindole Isothiocyanate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines for research chemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere (e.g., argon or nitrogen) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.