Description

1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its pyrazole core and acid chloride functionality. This compound matters for its critical role as a versatile building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, crop protection, and specialty chemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Ligand and Catalyst Development: Employed in organic synthesis to create novel pyrazole-based ligands for catalytic systems.
• Chemical Research & Development: A fundamental reagent for academic and industrial research in medicinal chemistry and heterocyclic compound synthesis.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development and scale-up projects.

Basic Information

Product Name	1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carbonyl Chloride
CAS No.	126674-98-4
Molecular Formula	C6H4ClF3N2O
Molecular Weight	212.56 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride; 1-Methyl-3-(trifluoromethyl)-4-pyrazolecarbonyl chloride; 4-Carbonyl chloride-1-methyl-3-trifluoromethylpyrazole; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride; 1-Methyl-3-trifluoromethylpyrazole-4-carbonyl chloride; 3-Trifluoromethyl-1-methylpyrazole-4-carbonyl chloride; Pyrazole-4-carbonyl chloride, 1-methyl-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all commercial quantities. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture ingress and decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.