Description

Quinupristin-Dalfopristin CAS NO 126602-89-9 is a synergistic, injectable antibiotic combination belonging to the streptogramin class. This compound is critically important for combating severe, multi-drug resistant Gram-positive bacterial infections, particularly those unresponsive to first-line treatments. It is primarily required by pharmaceutical manufacturers, clinical research organizations, and compounding pharmacies for the formulation of sterile injectable products and advanced antimicrobial research.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of sterile injectable antibiotic formulations.
• Treatment of Resistant Infections: Used in products targeting infections caused by vancomycin-resistant *Enterococcus faecium* (VREF) and complicated skin and skin structure infections.
• Clinical & Biomedical Research: Serves as a critical reference standard and investigational compound in studies of antibiotic resistance mechanisms and novel therapeutic strategies.
• Veterinary Pharmaceutical Development: Investigated for use in treating serious bacterial infections in animals.
• Microbiology & Diagnostics: Employed in laboratory settings for antimicrobial susceptibility testing and quality control of culture media.

Basic Information

Product Name	Quinupristin-Dalfopristin
CAS No.	126602-89-9
Molecular Formula	C72H84N10O17S (Quinupristin) • C34H50N4O9S (Dalfopristin)
Molecular Weight	1022.2 g/mol (Quinupristin) • 690.9 g/mol (Dalfopristin)
Synonyms	RP 59500; Synercid; Streptogramin B (Quinupristin); Streptogramin A (Dalfopristin); Quinupristin/Dalfopristin; Streptogramin Combination Antibiotic; Pristinamycin IA and IIA Combination; (3R,4S,5R,8R,9S,10S,11R,12S,13S,14S)-3-[(2S,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,5R,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-7,9,11-trimethyl-10-[[(2R,5S,6S)-5-(methylamino)-6-methyloxan-2-yl]oxy]oxacyclotetradecane-2,6-dione; (2R,3S,4R,5E,7S,8S,9S,12S,13S,15S,16S)-13-[[(2R,5S,6S)-5-(dimethylamino)-6-methyloxan-2-yl]oxy]-2,16-dimethyl-5,7,9,12,15-pentahydroxy-3,4,8-tris(2-methylbutanoyloxy)hexadec-5-en-15,16-olide
EINECS	Contact for details

Quality Control

Our Quinupristin-Dalfopristin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing purity, identity, and related substances are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (Total Quinupristin & Dalfopristin)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.5 EU/mg (for injectable grade)
Sterility	Sterile (for sterile grade, upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.