Description

2'-Fluoro-2'-Deoxy-N6-Methylarabinoadenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its unique structure, featuring a fluorine atom at the 2' position and an N6-methyl modification, is engineered to enhance metabolic stability and binding affinity in therapeutic applications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel antiviral agents, anticancer therapeutics, and advanced antisense oligonucleotides.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of modified antisense oligonucleotides (ASOs) and siRNA to improve nuclease resistance and pharmacokinetic profiles.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting viral polymerases and cellular enzymes.
• Biochemical Tool Development: Employed in the creation of enzyme inhibitors and molecular probes to study nucleic acid metabolism and related biological pathways.
• Preclinical Development: Supplies GMP or non-GMP material for formulation studies, pharmacokinetic testing, and toxicology assessments of candidate drug molecules.

Basic Information

Product Name	2'-Fluoro-2'-Deoxy-N6-Methylarabinoadenosine
CAS No.	126502-12-3
Molecular Formula	C11H14FN5O3
Molecular Weight	283.26 g/mol
Synonyms	2'-F-2'-d-N6-Me-ara-A; 2'-Fluoro-2'-deoxy-N6-methyl-9-β-D-arabinofuranosyladenine; N6-Methyl-2'-fluoro-2'-deoxyarabinoadenosine; 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-N6-methyladenine; 2'-F-N6-Me-araA; 2'-Fluoro-N6-methyl-arabinoadenosine; 2'-F-2'-deoxy-N6-methyladenosine arabinoside
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2'-Deoxy-N6-Methylarabinoadenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.