Description

Dalfopristin+Quinupristin is a synergistic combination of two semi-synthetic streptogramin antibiotics, known commercially as Quinupristin/Dalfopristin. This combination is critical for combating severe, multi-drug resistant Gram-positive bacterial infections where other therapeutic options have failed. It is an essential raw material for pharmaceutical manufacturers developing injectable antibiotic formulations, particularly for hospital-acquired infections.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of injectable antibiotic drugs.
• Research & Development of novel antibiotic combinations and delivery systems.
• Pharmaceutical Intermediates in the synthesis of advanced streptogramin derivatives.
• Reference Standard for quality control and analytical testing in pharmaceutical laboratories.
• Veterinary Medicine research for treating bacterial infections in animals.
• Microbiological Studies for investigating mechanisms of antibiotic resistance and synergy.

Basic Information

Product Name	Dalfopristin+Quinupristin
CAS No.	126202-89-9
Molecular Formula	C72H84N10O17S (Dalfopristin) • C53H67N9O10S (Quinupristin)
Molecular Weight	Dalfopristin: 1409.6 g/mol • Quinupristin: 1022.2 g/mol
Synonyms	Quinupristin/Dalfopristin; RP 59500; Synercid; Streptogramin B (Quinupristin); Streptogramin A (Dalfopristin); (3R,4S,5E,10E,12E,14S,26R,26aS)-26-[[(2S,5S,6R)-5-(Dimethylamino)-6-methyloxan-2-yl]oxy]-4-ethyl-3,5,10,12,14,26a-hexahydroxy-1,8,15,17,19-pentamethyl-9,16,18-trioxo-11,24-dioxa-2,7,20-triazatetracyclo[19.3.1.14,8.114,18]hexacosa-5,10,12,19-tetraen-23-one (Dalfopristin); (3R,4S,5E,10Z,12E,14S,26R,26aS)-26-[[(2S,5S,6R)-5-(Dimethylamino)-6-methyloxan-2-yl]oxy]-4-ethyl-3,5,10,12,14,26a-hexahydroxy-1,8,15,17,19-pentamethyl-9,16,18-trioxo-11,24-dioxa-2,7,20-triazatetracyclo[19.3.1.14,8.114,18]hexacosa-5,10,12,19-tetraen-23-one (Quinupristin)
EINECS	Contact for details

Quality Control

Our Dalfopristin+Quinupristin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (Total of Dalfopristin & Quinupristin)
Ratio (Quinupristin/Dalfopristin)	30:70 w/w
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Microbial Limits	Meets Ph. Eur. requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.