Description

2-Pyridinecarbonyl Chloride, 6-Methyl- (9Ci) is a versatile and highly reactive acid chloride derivative of picolinic acid, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 6-methylpicolinoyl moiety, a key structural motif in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the picolinoyl group can enhance biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Peptide Mimetics & Bio-conjugation: Employed in the acylation of amines to create amide bonds, useful in constructing peptide analogs and bioconjugates.
• Material Science Research: Acts as a monomer or functionalization agent in the development of polymers and functional organic materials.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 6-Methyl- (9Ci)
CAS No.	126125-54-0
Molecular Formula	C7H6ClNO
Molecular Weight	155.58 g/mol
Synonyms	6-Methylpicolinoyl Chloride; 2-Pyridinecarbonyl Chloride, 6-Methyl-; 6-Methylpyridine-2-carbonyl Chloride; 6-Methyl-2-pyridinecarboxylic Acid Chloride; 6-Methylpicolinic Acid Chloride; 2-Carboxy-6-methylpyridine Chloride; 6-Methyl-2-picolinoyl Chloride; Picolinoyl Chloride, 6-Methyl-
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonyl Chloride, 6-Methyl- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.