Description

8-Allylthioguanosine is a chemically modified nucleoside analog, specifically a thioguanosine derivative with an allylthio substitution at the 8-position. This structural modification is of significant interest for its potential role in biochemical research and pharmaceutical development, particularly in the study of nucleoside metabolism and as a precursor for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, antiviral research, and the synthesis of modified nucleic acids.

Application

• Medicinal Chemistry Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based drug candidates, particularly for antiviral and anticancer applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of purine nucleoside phosphorylases and other nucleoside-metabolizing enzymes.
• Antiviral Agent Development: Explored as a precursor for prodrugs or analogs targeting viral polymerases, given its modified purine scaffold.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., deuterated, C13) nucleosides for metabolic tracing and pharmacokinetic studies.
• Oligonucleotide Modification: Incorporated into synthetic oligonucleotides to alter their binding properties, stability, or for conjugation purposes in diagnostic probe development.
• Academic Research: Employed in university and institutional labs for fundamental studies on nucleic acid chemistry and structure-activity relationships (SAR).

Basic Information

Item	Detail
Product Name	8-Allylthioguanosine
CAS No.	126092-30-6
Molecular Formula	C13H17N5O4S
Molecular Weight	339.37 g/mol
Synonyms	8-(Allylthio)guanosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-(prop-2-en-1-ylsulfanyl)-3H-purin-6-one; 8-Allylsulfanylguanosine; 8-ATG; Allylthio-Guo; Guanosine, 8-(allylthio)-
EINECS	Contact for details

Quality Control

Our 8-Allylthioguanosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.