Description

5-Ethynyl-1-(5-o-Phosphonoribofuranosyl)Imidazole-4-Carboxamide is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel therapeutic agents, particularly in the field of antiviral and anticancer drug discovery. It is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Proteomics & Genomics: Employed in the development of probes and tools for studying nucleic acid interactions and cellular signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Development: Used in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Product Name	5-Ethynyl-1-(5-o-Phosphonoribofuranosyl)Imidazole-4-Carboxamide
CAS No.	126004-36-2
Molecular Formula	C11H14N3O8P
Molecular Weight	347.22 g/mol
Synonyms	5-Ethynyl-1-(5-O-phosphono-β-D-ribofuranosyl)imidazole-4-carboxamide; EICAR; 5-Ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate; NSC 693850; 5-Ethynylimidazole-4-carboxamide ribonucleotide; EICAR monophosphate; 5-Ethynyl-1-(5-O-phosphonoribofuranosyl)-1H-imidazole-4-carboxamide
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1-(5-o-Phosphonoribofuranosyl)Imidazole-4-Carboxamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.