Description

5-Ethynyl-1-(-D-Ribofuranosyl)-Imidazo-4-Carbonitrile is a specialized nucleoside analog building block of significant interest in advanced pharmaceutical research and development. Its unique molecular architecture, featuring an ethynyl group and a carbonitrile moiety on an imidazole ribofuranosyl scaffold, makes it a critical intermediate for the synthesis of novel antiviral and anticancer agents. This high-purity compound is essential for medicinal chemists and research institutions focused on nucleoside-based drug discovery, particularly in the development of polymerase inhibitors and targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Biochemical Probe Development: Serves as a building block for creating labeled compounds or probes for enzymatic studies.
• Nucleoside Chemistry: Fundamental research into modified nucleosides and their biological activities.
• Antiviral Drug Candidate Synthesis: Specifically targeted for the development of inhibitors against viral polymerases.
• Academic & Institutional R&D: Used in university and contract research organization (CRO) laboratories for exploratory drug discovery projects.

Basic Information

Product Name	5-Ethynyl-1-(-D-Ribofuranosyl)-Imidazo-4-Carbonitrile
CAS No.	126004-13-5
Molecular Formula	C11H11N3O4
Molecular Weight	249.22 g/mol
Synonyms	4-Cyano-5-ethynyl-1-β-D-ribofuranosylimidazole; 5-Ethynyl-1-β-D-ribofuranosyl-1H-imidazole-4-carbonitrile; 1-(β-D-Ribofuranosyl)-5-ethynylimidazole-4-carbonitrile; 5-Ethynyl-1-(β-D-ribofuranosyl)-1H-imidazole-4-carbonitrile; EICN; ERIC; 5-Ethynylimidazole ribonucleoside carbonitrile derivative
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1-(-D-Ribofuranosyl)-Imidazo-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for fine chemical production, ensuring reliable material for your critical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.