Description

Intoplicine is a synthetic, small-molecule compound belonging to the class of topoisomerase inhibitors, specifically identified by CAS No. 125974-72-3. This compound is of significant interest in advanced pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel oncology therapeutics.

Application

• Oncology Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for investigating anti-cancer mechanisms.
• Biochemical Assay Development: Used as a critical reagent in high-throughput screening (HTS) assays to identify and validate new drug candidates targeting DNA topoisomerases.
• Pharmacology Studies: Employed in in vitro and in vivo models to study pharmacokinetics, pharmacodynamics, and efficacy profiles.
• Chemical Intermediate: Acts as a sophisticated building block for the synthesis of more complex, derivative compounds with potentially enhanced therapeutic properties.
• Academic Research: Utilized in university and institutional labs for fundamental studies on cell cycle regulation, apoptosis, and DNA damage response pathways.

Basic Information

Product Name	Intoplicine
CAS No.	125974-72-3
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	NSC 645008; 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one; Intoplicine dihydrochloride (salt form); RP 60475; Topoisomerase I/II inhibitor; Indenoquinoline derivative
EINECS	Contact for details

Quality Control

Our Intoplicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.