Description

2'-Deoxyadenosine n-1-Oxide 3'-Monophosphate is a chemically modified nucleotide monophosphate derivative, serving as a critical building block and research tool in advanced biochemical applications. Its unique structure, featuring an N-oxide modification on the adenine base, makes it a valuable intermediate for studying nucleic acid chemistry, enzyme mechanisms, and for the synthesis of specialized oligonucleotides. This high-purity compound is essential for researchers and developers in the fields of pharmaceutical discovery, molecular biology, and diagnostic assay development.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel nucleoside analogs and prodrugs for antiviral and anticancer therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of kinases, polymerases, and other nucleotide-processing enzymes.
• Oligonucleotide Synthesis: A specialized phosphoramidite precursor for incorporating modified bases into synthetic DNA/RNA strands for diagnostic probes or aptamers.
• Diagnostic Reagent Manufacturing: Employed in the development and production of high-sensitivity molecular diagnostic kits and assays.
• Academic Research: A tool for fundamental studies in redox biology, nucleic acid damage, and repair pathways due to its oxidized base moiety.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in regulatory-compliant laboratories.

Basic Information

Product Name	2'-Deoxyadenosine n-1-Oxide 3'-Monophosphate
CAS No.	125927-62-0
Molecular Formula	C10H14N5O7P
Molecular Weight	347.22 g/mol
Synonyms	2'-Deoxyadenosine 1-N-oxide 3'-monophosphate; dA(N1-O) 3'-monophosphate; 2'-Deoxy-1-oxoadenosine 3'-(dihydrogen phosphate); 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-1-oxo-1,9-dihydro-6H-purin-6-one 3'-monophosphate; 1-Oxo-2'-deoxyadenosine 3'-monophosphate; 2'-dA1O 3'-MP; N1-Oxide of 2'-Deoxyadenosine 3'-Monophosphate; Modified Nucleotide Monophosphate
EINECS	Contact for details

Quality Control

Our 2'-Deoxyadenosine n-1-Oxide 3'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.