Description

5'-Isoleucyl 3'-Azido-3'-Deoxythymidine is a chemically modified nucleoside analog, specifically a prodrug derivative of the antiviral compound AZT (Zidovudine). This compound matters for its role as a key synthetic intermediate in advanced pharmaceutical research, enabling the development of targeted antiviral therapies with potentially enhanced efficacy and reduced side effects. It is primarily needed by research scientists and process chemists in the pharmaceutical and biotechnology industries working on novel antiviral agents, prodrug strategies, and nucleoside chemistry.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nucleoside-based antiviral prodrugs.
• Antiviral Research: Used in biochemical and pharmacological studies to investigate mechanisms of action against retroviruses like HIV.
• Prodrug Development: Serves as a model compound for designing amino acid ester prodrugs to improve the bioavailability and cellular uptake of therapeutic nucleosides.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Bioconjugation: The azido functional group allows for site-specific modifications via click chemistry for labeling or creating drug conjugates.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5'-Isoleucyl 3'-Azido-3'-Deoxythymidine
CAS No.	125780-95-2
Molecular Formula	C17H24N6O6
Molecular Weight	408.41 g/mol
Synonyms	3'-Azido-3'-deoxythymidine 5'-(2-methylbutanoate); AZT 5'-Isoleucinate; Zidovudine 5'-Isoleucyl Ester; 5'-O-(L-Isoleucyl)-3'-azido-3'-deoxythymidine; 3'-Azido-5'-O-[(2S,3S)-2-methyl-1-oxopent-3-yl]-3'-deoxythymidine; 5'-Isoleucinylazidothymidine; L-Isoleucyl AZT Ester
EINECS	Contact for details

Quality Control

Our 5'-Isoleucyl 3'-Azido-3'-Deoxythymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.